PT-141 – 10mg
$70.00
PT-141 (Bremelanotide) is a potent, synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (-MSH). As a non-selective agonist of the melanocortin receptors, particularly MC3R and MC4R, PT-141 is a primary tool for investigating the central nervous system’s regulation of sexual motivation and physiological arousal. Each 10mg vial is vacuum-sealed and guaranteed at 99% purity, providing the chemical stability required for high-precision neuroendocrine and behavioral studies.
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Description
Overview of PT-141
PT-141 is a metabolic byproduct of the tanning peptide Melanotan 2, but it lacks the C-terminal amide group, which shifts its primary activity away from pigmentation and toward the central nervous system. Unlike traditional pharmacological agents that target the vascular system, PT-141 acts directly on the brain’s hypothalamus to trigger arousal signals.
Because it bypasses the cardiovascular system to initiate its effects through the neural pathways, it is a premier subject for researchers studying the “arousal circuit” and the complex interplay between dopaminergic signaling and melanocortin activation.
Primary Research Applications
This 10mg formulation is a cornerstone of neurobiology and sexual medicine research, utilized to explore:
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Central Arousal Mechanisms: Investigating how the activation of MC4 receptors in the medial preoptic area (mPOA) of the hypothalamus triggers sexual desire and physiological response.
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Dopamine Modulation: Researching the synergistic relationship between melanocortin agonists and the release of dopamine in the mesolimbic “reward” pathway.
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Hypoactive Sexual Desire Disorder (HSDD): Studying the peptide’s ability to restore sexual motivation in animal models characterized by behavioral inhibition or hormonal imbalances.
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Non-Vascular Vasodilation: Analyzing the neural triggers for erectile response that occur independently of nitric oxide pathways.
