MOTS-C – 10mg
$50.00
MOTS-c (10mg) is a cutting-edge mitochondrial-derived peptide (MDP) consisting of 16 amino acids. Unlike nuclear-encoded peptides, MOTS-c is encoded by the mitochondrial genome and acts as a specialized signaling molecule that regulates metabolic homeostasis. It is a premier tool for researchers investigating the “mitochondrial-to-nuclear” retrograde signaling pathway, exercise mimetics, and glucose metabolism. Each vial is vacuum-sealed and guaranteed at 99% purity for high-precision systemic and cellular research.
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Description
Overview of MOTS-c
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a unique peptide that translocates to the nucleus in response to metabolic stress. Once in the nucleus, it binds to specific response elements to modulate gene expression related to antioxidant defenses and glucose uptake.
Often referred to as an “exercise mimetic,” MOTS-c is studied for its ability to activate the AMPK (AMP-activated protein kinase) pathway, similar to the effects of physical exertion. This 10mg formulation allows for rigorous exploration of how mitochondrial signaling can influence whole-body insulin sensitivity and energy expenditure.
Primary Research Applications
This peptide is a cornerstone of longevity and metabolic research, utilized to explore:
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AMPK Pathway Activation: Investigating how MOTS-c increases the levels of AICAR (an AMPK activator) to enhance fatty acid oxidation and glucose disposal.
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Insulin Sensitivity: Researching the peptide’s ability to prevent insulin resistance in animal models fed high-fat diets.
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Osteogenesis & Bone Health: Studying the role of MOTS-c in promoting the differentiation of mesenchymal stem cells into osteoblasts, potentially mitigating bone loss.
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Longevity and Aging: Analyzing the decline of endogenous MOTS-c levels with age and the effects of supplementation on cellular senescence and lifespan extension in laboratory models.
