IGF-1LR3 – 1mg
$75.00
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a highly potent, synthetic analog of endogenous IGF-1, specifically engineered for extended biological activity. By incorporating a 13-amino acid N-terminal extension and a substitution of Arginine for Glutamic Acid at position 3, this peptide is designed to bypass IGF-binding proteins (IGFBPs), significantly increasing its half-life and potency. Each 1mg vial is vacuum-sealed and guaranteed at 99% purity, making it an essential tool for researching cellular proliferation, muscle hypertrophy, and glucose transport.
Out of stock
Description
Overview of IGF-1 LR3
IGF-1 LR3 is a 83-amino acid polypeptide that represents the pinnacle of growth factor research. The “LR3” modification addresses the primary limitation of native IGF-1: its rapid neutralization by binding proteins. By preventing these proteins from latching onto the peptide, IGF-1 LR3 remains active in the system for up to 20–30 hours, compared to the 20-minute half-life of standard IGF-1. This allows researchers to observe sustained activation of the AKT/mTOR pathway, which is the primary driver of protein synthesis and cellular growth.
Primary Research Applications
This 1mg formulation is a cornerstone of molecular biology and regenerative medicine, utilized to explore:
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Hyperplasia and Hypertrophy: Investigating the mechanisms of “muscle cell splitting” (hyperplasia) and the proliferation of satellite cells in musculoskeletal models.
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Nutrient Partitioning: Researching how IGF-1 signaling facilitates the transport of glucose and amino acids into muscle cells, potentially bypassing traditional insulin pathways.
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Tissue Repair and Recovery: Analyzing the peptide’s role in accelerating the repair of connective tissues, nerves, and skin following induced injury in laboratory settings.
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Survival Signaling: Studying the inhibition of apoptosis (programmed cell death) and the promotion of cellular longevity in specialized cell lines.
