HCG – 5000iu
$70.00
HCG (Human Chorionic Gonadotropin) is a highly purified glycoprotein hormone consisting of 237 amino acids. In research settings, HCG is utilized as a potent analog of Luteinizing Hormone (LH), capable of binding to and activating the LH/choriogonadotropin receptor (LHCGR). This 5000iu (International Units) vial is an essential reagent for investigating the regulation of the hypothalamic-pituitary-gonadal (HPG) axis, steroidogenesis, and follicular development. Every vial is vacuum-sealed and guaranteed at 99% purity, ensuring the biological activity required for high-fidelity endocrine studies.
4 in stock
Description
Overview of HCG
HCG is a heterodimeric glycoprotein composed of an alpha and a beta subunit. While naturally produced by the placenta during pregnancy, its alpha subunit is identical to those of LH, FSH, and TSH, while its beta subunit is unique but shares significant sequence homology with LH.
Because HCG has a significantly longer half-life than endogenous LH (approximately 24–36 hours vs. 20–30 minutes), it is the primary tool used by researchers to simulate sustained gonadotropic signaling. In the laboratory, it is used to stimulate the Leydig cells in males to produce testosterone and the theca cells in females to regulate ovulation and progesterone production.
Primary Research Applications
This 5000iu formulation is a cornerstone of reproductive and endocrine research, utilized to explore:
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Steroidogenesis Induction: Investigating the biochemical pathways that convert cholesterol into testosterone or estrogen within gonadal tissues.
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HPG Axis Recovery: Researching the “restart” mechanisms of endogenous hormone production following suppression in animal models.
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Follicular Maturation: Studying the final stages of oocyte maturation and the triggers for ovulation in reproductive biology models.
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LHCGR Sensitivity: Analyzing receptor down-regulation and sensitivity when exposed to varying concentrations of gonadotropic analogs.
