CJC-1295 WO/Dac – 5mg
$40.00
CJC-1295 No DAC (also known as MOD GRF 1-29) is a sterile, lyophilized 29-amino acid peptide and a highly potent analog of Growth Hormone-Releasing Hormone (GHRH). Unlike the version with DAC, this “No DAC” variant is designed for researchers studying the pulsatile release of endogenous growth hormone, mimicking the natural physiological rhythm of the pituitary gland. Each vial is vacuum-sealed and guaranteed at 99% purity, providing the structural integrity required for high-precision endocrine and metabolic research.
Out of stock
Description
Overview of CJC-1295 No DAC (MOD GRF 1-29)
CJC-1295 No DAC is a tetrasubstituted analog of the shortest fully functional fragment of GHRH, known as GRF 1-29. By replacing four specific amino acids in the sequence, the peptide is made significantly more resistant to enzymatic cleavage by dipeptidyl peptidase-IV (DPP-IV).
In a research setting, the “No DAC” version is preferred when the objective is to observe acute, transient spikes in growth hormone. Because it lacks the Drug Affinity Complex, it has a half-life of approximately 30 minutes, allowing for multiple, controlled experimental simulations within a single research cycle.
Primary Research Applications
This formulation is a fundamental reagent in metabolic and aging-related studies, used to explore:
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Pulsatile GH Stimulation: Investigating how transient GHRH receptor activation influences the natural secretion of growth hormone from somatotropic cells.
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Synergistic Growth Signaling: Researching the “stacking” effect when paired with GHRPs (like Ipamorelin) to study the amplified GH response via dual-pathway activation.
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Cellular Repair and Recovery: Analyzing the impact of acute GH elevation on the repair of muscle tissue, bone density, and wound healing in animal models.
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Metabolic Substrate Utilization: Studying the short-term effects of GHRH analogs on lipolysis and glucose metabolism.
